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Testosterone gel: reviews, indications and side effects

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Andriol; Androgel; Durandron; Nebido; Nuvir; Omnadren; Omnadren 250; Sustanon; Sustanon-250; Sustaretard; Sustaretard-250; Testosterone; Testosterone propionate; Testosterone andekanoat; Testosterone izokapronat; Testosterone caprate; Testosterone propionate; Testosterone fenilopropionat; Testosterone enanthate; Testenat; Tetrasteron.

Testosterone – the male sex hormone, has a distinct androgenic effect which is coupled with a strong anabolic effect. Suitable for men in the endocrine impotence, oligospermia, symptoms of male menopause, post-castration syndrome, osteoporosis; in women with Hyperestrogenism, uterine fibroids, endometriosis, breast cancer, osteoporosis. Details

Active-active substance:

Testosterone / Testosterone.

Formulations:

  • Pills.
  • Capsules.
  • Injection.
  • Gel.

Testosterone

Properties / Action:

Testosterone is necessary for normal growth and development of male sex organs and secondary sex characteristics (growth, deep voice, growth of beard and mustache). The adult male is necessary to maintain libido and general condition, sexual potency, the functions of the prostate and seminal vesicles. When used for therapeutic purposes is marked increase in the concentration of testosterone, dihydrotestosterone, androstenedione in plasma, as well as reducing binding globulin sex steroids. Men with primary hypogonadism hypergonadotrophic observed normal levels of gonadotropins.

In the female body, testosterone exhibits antagonistic action with respect to estrogens (treatment of fibroids, endometriosis, cancer of breast nipple). It shows a beneficial effect during menopause complaints.

As for the impact vnegonadnyh anabolic action both women and men. There is a strong strength gain while adding body weight.

Testosterone propionate has a rapid onset and short duration of action.

Testosterone phenylpropionate and izokaproat characterized by slow onset and long duration of action.

Testosterone decanoate is characterized by the slow onset and long duration of action itself.

Testosterone andekanoat – fatty acid esters of natural testosterone, oral activity. Testosterone in pure form with oral activity. Testosterone andekanoat oral application is not subjected to primary hepatic metabolism, and is distributed in the lymphatic system and thus retains its activity. When applying andekanoata Testosterone plasma levels rise as the testosterone and its active metabolites, which makes stable therapeutic effect. Testosterone andekanoat well tolerated and, unlike oral activity C-17-methylated derivatives of testosterone does not affect the function of the liver.

Indications:

Men – hormone replacement therapy in disorders associated with testosterone deficiency:

  • delayed puberty;
  • syndrome, underdevelopment of genitals;
  • endocrine impotence, oligospermia caused by violation of spermatogenesis;
  • hypopituitarism;
  • Symptoms of male menopause (decreased libido, mental and physical activity);
  • post-castration syndrome (androgen deficiency after castration);
  • Osteoporosis due to androgen deficiency.
  • Among women:
  • hyperestrogenism, functional bleeding;
  • uterine fibroids;
  • endometriosis;
  • menopause (combined with estrogens);
  • premenstrual tension;
  • mammary cancer;

Dosage and administration:

Inside (capsules, tablets) / m (oil solutions of the individual esters or combinations thereof).

The dosage regimen is selected individually depending on the disease, sex, age, clinical effect, and dosage forms.

The capsules (tablets) of testosterone should be taken after a meal, if necessary with a small amount of fluid and swallowing whole, without chewing. It is advisable to take half the dose in the morning and the other half – in the evening. If it is an odd number of capsules, the higher dose is taken in the morning. It is usually adequate initial dose of 120-160 mg per day for 2-3 weeks, followed by assignment of 40-120 mg per dose per day. Read more

Usually administered intramuscularly 1 ampoule solution of testosterone every 3 – 4 weeks.

Gel for external use:

The recommended dose of 5 grams of gel (50 mg of testosterone), used 1 time per day at about the same time, preferably in the morning. Individual daily dose may be adjusted by the physician according to clinical and laboratory parameters of patients, but does not exceed 10 g of gel per day. Correction mode should be performed in steps of 2.5 g of gel per day. The gel is applied to clean, dry, intact skin of the shoulders, arms and / or abdomen. Apply to the skin and spread a thin layer. It is not necessary to rub it into the skin. Let it dry for at least 3-5 minutes before dressing. After applying the gel, wash your hands with soap and water.

Overdose:

In the acute toxicity of testosterone overdose is extremely low.

In chronic overdose may develop priapism. In this case, treatment should be discontinued, and after the disappearance of symptoms – start at lower doses.

Contraindications:

  • hypersensitivity;
  • verified or suspected carcinoma of the breast or prostate;
  • prostatic hypertrophy with symptoms of urination;
  • nephrosis or the nephrotic phase of nephritis, edema;
  • hypercalcemia;
  • abnormal liver function;
  • diabetes;
  • cardiac and coronary insufficiency, myocardial infarction, atherosclerosis in older men;
  • pregnancy, breast-feeding.

Side effect:

Androgen therapy may be accompanied by the following adverse reactions:

  • priapism and other signs of excessive sexual stimulation (frequent erection);
  • boys in prepubertal – accelerated sexual development, increased frequency of erections, penis enlargement and premature closure of the epiphysis;
  • damage spermatogenesis and sperm maturation violation, oligospermia and decreased volume of ejaculate;
  • prostate abnormalities;
  • bleeding from the birth canal, increased libido in women;
  • hirsutism, gynecomastia;
  • seborrhea, acne, oily skin, accelerated hair loss;
  • sodium and water retention, edema;
  • Symptoms of hypercalcemia;
  • thrombophlebitis;
  • nausea, cholestatic jaundice, increased liver transaminases (as the discontinuation of normalized);
  • headache, depression, aggression, anxiety, insomnia, paresthesia.

At the injection site may occur pain, itching, redness.

Cautions and precautions:

To adjust the dose of testosterone replacement therapy is necessary to determine the concentration of testosterone in serum. The dosage can be reduced if the content of testosterone in the plasma is increased. If low concentrations, the dose can be increased.

In the event of adverse reactions androgen testosterone treatment should be discontinued. After the disappearance of the side effects resume treatment at lower doses.

Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or the existence of these states in history) shall be subject to ongoing monitoring, since androgens may in some cases cause sodium and water retention.

The boys at prepubertal androgens should be used with caution in order to avoid premature epiphyseal closure and accelerated sexual development.

Perhaps lowering belkosvyazannogo iodine (BSY), but this has no clinical significance.

Drug Interactions:

Testosterone increases the effect of indirect anticoagulants (warfarin, nikumalon, fenilin) ​​and hypoglycemic agents, inhibits the excretion of cyclosporin. Barbiturates and alcohol decrease action.

Storage conditions:
List B. In the dark place at a temperature of 8-25 ° C.
The expiration date on the package.
Conditions of supply of pharmacies – prescription.

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